https://deisygysi.github.io/categories/genetics/Recent content in Genetics on Wonderland of Deisy GysiHugo -- gohugo.ioenTue, 01 Sep 2026 00:00:00 +0000https://deisygysi.github.io/projects/nutrition-genetics/Tue, 01 Sep 2026 00:00:00 +0000https://deisygysi.github.io/projects/nutrition-genetics/Summary People can respond differently to the same diet because nutrition operates within a broader system shaped by genetic variation, metabolism, environment and social context. Nutrigenomics and precision nutrition seek to understand these differences and translate them into more relevant health strategies. This emerging research direction will integrate genomic, nutritional, clinical and population-level data. A central aim is to study variation across diverse populations while avoiding models that treat genetic effects independently from access to care, socioeconomic conditions and other determinants of health.https://deisygysi.github.io/publications/ironhomeostasis/Fri, 06 Dec 2024 00:00:00 +0000https://deisygysi.github.io/publications/ironhomeostasis/Abstract Iron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported. Mapping to putative genes indicated involvement in iron-trait expression, erythropoiesis, immune response and cellular trafficking.