iron homeostasis on Wonderland of Deisy Gysihttps://deisygysi.github.io/categories/iron-homeostasis/Recent content in iron homeostasis on Wonderland of Deisy GysiHugo -- gohugo.ioenFri, 06 Dec 2024 00:00:00 +0000Novel Loci and Biomedical Consequences of Iron Homoeostasis Variationhttps://deisygysi.github.io/publications/ironhomeostasis/Fri, 06 Dec 2024 00:00:00 +0000https://deisygysi.github.io/publications/ironhomeostasis/Abstract Iron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported. Mapping to putative genes indicated involvement in iron-trait expression, erythropoiesis, immune response and cellular trafficking.